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Genetic engineering, CRISPR and food: What the ‘revolution’ will bring in the near future

On 24, Jan 2018 | No Comments | In Blog, Featured, Future of Agriculture | By admin

January 24, 2018

Humankind is on the verge of a genetic revolution that holds great promise and potential. It will change the ways food is grown, medicine is produced, animals are altered and will give rise to new ways of producing plastics, biofuels and chemicals.

Many object to the genetic revolution, insisting we should not be ‘playing God’ by tinkering with the building blocks of life; we should leave the genie in the bottle. This is the view held by many opponents of GMO foods.  But few transformative scientific advances are widely embraced at first. Once a discovery has been made and its impact widely felt it is impossible to stop despite the pleas of doubters and critics concerned about potential unintended consequences. Otherwise, science would not have experienced great leaps throughout history­­—and we would still be living a primitive existence.

Gene editing of humans and plants—a revolutionary technique developed just a few years ago that makes genetic tinkering dramatically easier, safer and less expensive—has begun to accelerate this revolution. University of California-Berkeley biochemist Jennifer Doudna, one of the co-inventors of the CRISPR technique::

Within the next few years, this new biotechnology will give us higher-yielding crops, healthier livestock, and more nutritious foods. Within a few decades, we might well have genetically engineered pigs that can serve as human organ donors…we are on the cusp of a new era in the history of life on earth—an age in which humans exercise an unprecedented level of control over the genetic composition of the species that co-inhabit our planet. It won’t be long before CRISPR allows us to bend nature to our will in the way that humans have dreamed of since prehistory.

The four articles in this series will examine the dramatic changes that gene editing and other forms of genetic engineering will usher in.

Great advances likely for GE foods

Despite the best efforts of opponents, GE crops have become so embedded and pervasive in the food systems—even in Europe which has bans in place on growing GMOs in most countries—that it is impossible to dislodge them without doing serious damage to the agricultural sector and boosting food costs for consumers.

Even countries which ban the growing of GMOs or who have such strict labeling laws that few foods with GE ingredients are sold in supermarkets are huge consumers of GE products.

revolution 1 5 18 2Europe is one of the largest importers of GMO feed in the world. Most of the meat we consume from cattle, sheep, goats, chickens, turkeys, pigs and fish farms are fed genetically modified corn, soybeans and alfalfa.

And the overwhelming majority of cheesesare made with an enzyme produced by GM microbes and some beers and wines are made with genetically engineered yeast.

North America, much of South America and Australia are major consumers of foods grown from GE seeds. Much of the corn oil, cotton seed oil, soybean oil and canola oil used for frying and cooking, and in salad dressings and mayonnaise is genetically modified. GM soybeans are used to make tofu, miso, soybean meal, soy ice cream, soy flour and soy milk. GM corn is processed into corn starch and corn syrup and is used to make whiskey.  Much of our sugar is derived from GM sugar beets and GE sugarcane is on the horizon. Over 90 percent of the papaya grown in Hawaii has been genetically modified to make it resistant to the ringspot virus.  Some of the squash eaten in the US is made from GM disease-resistant seeds and developing countries are field testing GM disease-resistant cassava.

Many critics of GE in agriculture focus on the fact that by volume most crops are used in commodity food manufacturing, specifically corn and soybeans. One reason for that is the high cost of getting new traits approved. Indeed, research continues on commodity crops, although many of the scientists work for academia and independent research institutes.

For example, in November 2016, researchers in the UK were granted the authority to begin trials of a genetically engineered wheat that has the potential to increase yields by 40 percent. The wheat, altered to produce a higher level of an enzyme critical for turning sunlight and carbon dioxide into plant fuel, was developed in part by Christine Raines, the Head of the School of Biological Sciences at the University of Essex.

Genetic engineering and nutrition enhancement

 A new generation of foods are now on the horizon, some as the result of new breeding techniques (NBTs), such as gene editing.  Many of these foods will be nutritionally fortified, which will be critical to boosting the health of many of the poorest people in developing nations and increase yields.

Golden rice is a prime example of such a nutrition-enhanced crop.  It is genetically engineered to have high levels of beta carotene, a precursor of Vitamin A. This is particularly important as many people in developing countries suffer from Vitamin A deficiency which leads to blindness and even death. Bangladesh is expected to begin cultivation of golden rice in 2018. The Philippines may also be close to growing it.

revolution 1 5 18 3strain of golden rice that includes not only high levels of beta carotene but also high levels of zinc and iron could be commercialized within 5 years. “Our results demonstrate that it is possible to combine several essential micronutrients – iron, zinc and beta carotene – in a single rice plant for healthy nutrition,” said Navreet Bhullar, senior scientist at ETH Zurich, which developed the rice.

The Science in the News group at Harvard University discussed some of the next generation foods.

Looking beyond Golden Rice, there are a large number of biofortified staple crops in development.  Many of these crops are designed to supply other micronutrients, notably vitamin E in corn, canola and soybeans…Protein content is also a key focus; protein-energy malnutrition affects 25% of children because many staple crops have low levels of essential amino acids.  Essential amino acids are building blocks of proteins and must be taken in through the diet or supplements. So far, corn, canola, and soybeans have been engineered to contain higher amounts of the essential amino acid lysine. Crops like corn, potatoes and sugar beets have also been modified to contain more dietary fiber, a component with multiple positive health benefits.

Other vitamin-enhanced crops have been developed though they have yet to be commercialized.  Australian scientists created a GE Vitamin A enriched banana, scientists in Kenya developed GE Vitamin A enhanced sorghum and plant scientists in Switzerland developed a GE Vitamin B6 enhanced cassava plant. None is near approval, however.

Scientists genetically engineered canola, a type of rapeseed, to produce additional omega-3 fatty acids. Research is being conducted on developing GM gluten free wheat and vegetables with higher levels of Vitamin E to fight heart disease.

Other more consumer-focused genetically-engineered crops that do not use transgenics, and have sailed through the approval system include:

  • FDA has approved the commercialization of a GE non-browning applethe Arctic Apple, developed by using a gene-silencing technique.
  • Simplot has developed GE potatoes created using gene-silencing techniques.  They are less prone to bruising and blackening, in some cases are resistant to certain diseases and also contain less asparagine which reduces the potential for acrylamide that is created when frying, baking and roasting.

Fighting plant diseases

Other products are in development that fight viruses and disease.  Scientists have used genetic engineering to develop disease-resistant rice.  A new plum variety resists the plum pox virus.  It has not yet been commercialized.  GE solutions may be the only answer to save the orange industry from citrus greeningwhich is devastating orange groves in Florida.  GE might be utilized to curb the damage caused by stem rust fungus in wheat and diseases effecting the coffee crop.

revolution 1 5 18 4In Africa, GE solutions could be used to combat the ravages of banana wilt and cassava brown streak disease and diseases that impact cocoa trees and potatoes. A GE bean has been developed in Brazil that is resistant to the golden mosaic virus.  Researchers at the University of Florida, the University of California-Berkeley and the 2Blades Foundation have developed a disease resistant GM tomato.

Scientists at the John Innes Center in the UK are attempting to create a strain of barley capable of making its own ammonium fertilizer from nitrogen in the soil. This would be particularly beneficial to farmers who grow crops in poor soil conditions or who lack the financial resources to buy artificial fertilizers.

Peggy Ozias-Akins, a horticulture expert at the University of Georgia has developed and tested genetically-engineered peanuts that do not produce two proteins linked to intense allergens.

New Breeding Techniques

New gene editing techniques (NBTs) such as CRISPR offer great potential and face lower approval hurdles, at least for now.

  • Scientists at Penn State have removed the gene that causes white button mushrooms to discolor, and the product was quickly approved.
  • In 2014, scientists in China produced bread wheat resistant to powdery mildew.
  • Calyxt, a biotechnology company, has developed a potato variety that prevents the accumulation of certain sugars, reducing the bitter taste associated with storage. The potato also has a lower amount of acrylamide.
  • DuPont has developed a gene-edited variety of cornwhich can be used to thicken food products and make adhesives.

In June, the EPA approved a new first of its kind GE corn known as SmartStaxPro, in which the plant’s genes are tweaked without transgenics to produce a natural toxin designed to kill western corn rootworm larvae.  It also produces a piece of RNA that shuts down a specific gene in the larvae, thereby killing them. The new GE corn is expected to be commercialized by the end of the decade.

What could slow—or even stop—this revolution? In an opinion piece for Nature Biology, Richard B. Flavell, a British molecular biologist and former director of the John Innes Center in the UK, which conducts research in plant science, genetics and microbiology, warned about the dangers of vilifying and hindering new GE technologies:

The consequences of simply sustaining the chaotic status quo—in which GMOs and other innovative plant products are summarily demonized by activists and the organic lobby—are frightening when one considers mounting challenges to food production, balanced nutrition and poverty alleviation across the world.  Those who seek to fuel the GMO versus the non-GMO debate are perpetuating irresolvable difference of opinion. …Those who seek to perpetuate the GMO controversy and actively prevent use of new technology to crop breeding are not only on the wrong side of the debate, they are on the wrong side of the evidence. If they continue to uphold beliefs against evidence, they will find themselves on the wrong side of history.

Steven E. Cerier is a freelance international economist and a frequent contributor to the Genetic Literacy Project.

02

Aug
2017

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Featured

By admin

10 myths about farming to remember on your next grocery run

On 02, Aug 2017 | No Comments | In Blog, Featured | By admin

Most of us don’t spend our days plowing fields or wrangling cattle. We’re part of the 99 percent of Americans who eat food but don’t produce it. Because of our intimate relationship with food and because it’s so crucial to our health and the environment, people should be very concerned about how it’s produced. But we don’t always get it right. Next time you’re at the grocery store, consider these 10 modern myths about the most ancient occupation. Read more…

Building Bee Resilience, One Queen At A Time

On 28, Jun 2017 | No Comments | In Blog, Featured, Pollinator Health | By admin

Published on VPR

Originally published on June 27, 2017 11:49 am

Listen to the full recording here. Read more…

For dairy farmers, every day is Earth Day

On 20, Apr 2017 | No Comments | In Blog, Featured, GMO’s and The Environment | By admin

Millions of people around the world will soon celebrate Earth Day, but for hundreds of New England’s dairy farmers, every day is Earth Day.

We’re talking about farmers like the Erb family. The Erbs own and operate Springvale Farms and Landaff Creamery in Landaff. This was one of three pilot farms that assisted the Manomet Center for Conservation Sciences in creating an on-farm sustainability assessment tool, called the Vital Capital Index for Dairy Agriculture. This tool allows farms to measure what matters and establish a baseline of sustainability on farms. Read more…

USDA letter on federal GMO labeling law

On 02, Mar 2017 | No Comments | In Blog, Featured, GMO Labeling, Uncategorized | By admin

On July 29, 2016, President Obama signed into law an Act amending the Agricultural Marketing at of 1946 which provides for a national bioengineered food disclosure standard. The FDA sent letters to Governor Malloy explaining that under this new law there is no longer a need for state-specific labeling laws given that the Federal Government had set a uniform standard.

Click on the link below to see the letter.

Connecticut

How People, Water and Agriculture Connect – Food Insight

When you think of water, what comes to mind? Is it a cool swig after a hard workout? Is it your beach vacation from last year? Or is it whether or not enough water will fall from the sky to grow your food?

March 22 is World Water Day, and it’s an opportunity to reflect on the importance of water. This year’s theme is “better water, better jobs.” How does water impact agriculture, which employs nearly 1 billion people around the world? Let’s take a look.

Although nearly 70 percent of the Earth is covered in water, only 2.5 percent of that water is fresh. To complicate things, only 1 percent of that fresh water is easily accessible. To sum it up, only 0.025 percent of the planet’s water is available for human use.

Agriculture uses a lot of water, accounting for almost 70 percent of all withdrawals and up to 95 percent in developing countries where there may be fewer technologies to make water use efficient. While you only need to drink about a gallon of water per day, it takes 528 to 1,320 gallons of water to grow the food you eat in a single day. Think about that.

Water is important in maintaining food security, which is defined as “regular access of people to enough high-quality food to leave active, healthy lives.” Lack of water, or too much water, can contribute to famine and undernourishment, especially where people depend on local agriculture for their livelihood. Using water efficiently is critical.

Irrigation is an important technology to help maximize the efficiency of water use in agriculture. The highest yields that can be obtained from irrigation are more than double the best yields from rain-fed agriculture. For instance, drip irrigation involves distributing water at very low rates from a system of plastic pipes with outlets called emitters or drippers. The water is released so that the only part of the soil that receives moisture is where the root grows.

Read the entire article and learn more about agricultural innovation here.picture-79-1403036319

21

Feb
2015

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Featured

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No GMO Label Needed

On 21, Feb 2015 | No Comments | In Blog, Featured | By admin

At first blush, it sounds like a good idea: require the labeling of genetically engineered foods so that consumers can make informed choices about what they eat. Yet such a law, proposed by U.S. Sen. Richard Blumenthal and other senators, simply caters to unjustified worries and makes no sense scientifically.

Genetically modified food isn’t new. Since farming began, humans have been breeding food — in other words, changing the genetics — for beneficial traits and better crops. The practice has moved from the field to the lab, as scientists can now transplant genes from species to species.

The laboratory angle worries some people, and in recent years about 2,000 studies have been done on genetically modified foods to uncover any problem. The result? According to the American Medical Association, the World Health Organization, the National Academies of Science and several other groups, so-called GMO food — made with genetically modified organisms — is safe.

As the European Commission put it, engineering crops genetically is “no more risky than conventional plant-breeding techniques.”

Despite the failure of research to come up with hazards, what’s wrong with better informing consumers by labeling genetically engineered food? Several things.

Such a move doesn’t inform consumers so much as it caters to misconceptions, and government shouldn’t be about that. Labels may limit consumer choice: Despite the lack of proof that such crops endanger anyone, retailers may choose not to stock certain foods. And mostly, politics shouldn’t trump science.

Perhaps the oddest aspect of the genetically engineered label debate is that the labels already exist, in a sense.

The majority of food found in the supermarket, especially processed food, contains some genetically engineered component. Non-engineered items routinely carry the label “USDA Organic.”

Lack of such a designation almost always indicates some genetic engineering, so those who are worried about a potential hazard need only look for the label. No new law is necessary.

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03

Feb
2015

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Seed Treatments

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89% Of Scientists Believe Genetically Modified Foods Are Safe

On 03, Feb 2015 | No Comments | In Featured, Seed Treatments | By admin

Pew Research Center study on science literacy, undertaken in cooperation with the American Association for the Advancement of Science (AAAS), and released on January 29, contains a blockbuster: In sharp contrast to public skepticism about GMOs, 89% of scientists believe genetically modified foods are safe.

That overwhelming consensus exceeds the percentage of scientists, 88%, who believe global warming is the result of human activity. However, the public appears far more suspicious of scientific claims about GMO safety than they do about the consensus on climate change.

Some 57 percent of Americans say GM foods are unsafe and a startling 67% do not trust scientists, believing they don’t understand the science behind GMOs. Scientists blame poor reporting by mainstream scientists for the trust and literacy gaps.

The survey also contrasts sharply with a statement published earlier this week in a marginal pay-for-play European journal by a group of anti-GMO scientists and activists, including Michael Hansen of the Center for Food Safety, and philosopher Vandana Shiva, claiming, “no scientific consensus on GMO safety.”

A huge literacy gap between scientists and the public on biotechnology is one of the many disturbing nuggets that emerged from the Pew Research Center survey, which was conducted in cooperation with the AAAS, the world’s largest independent general scientific society. The full study, released on January 29, is available here.

This survey, the first of several reports to be released in coming months, compares the views of scientists and the general public on the role of science in the United States and globally.

The eye opening take-away: The American population in general borders on scientific illiteracy. The gap between what scientists believe, grounded on empirical evidence, often sharply differs from what the general public thinks is true. The differences are sharpest over biomedical research, including GMOs.

  • 88% of AAAS scientists think eating GM food is safe, while only 37% of the public believes that’s true—a 51-percentage point gap
  • 68% of scientists say it is safe to eat food grown with pesticides, compared with 28% of citizens—a 40% gap.
  • A 42-percentage point gap over the issue of using animals in research—89% of scientists favor it, while only 47% of the public backs the idea.

11

Apr
2014

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House Defeats GMO Grass Seed Ban

On 11, Apr 2014 | No Comments | In Featured | By admin

by Christine Stuart

Less than 24 hours after the Senate approved a bill banning genetically modified grass seed, the House found bipartisan agreement to kill it.

The bill was a top priority for outgoing Senate President Donald Williams. But House Speaker Brendan Sharkey was not sold on the idea or consulted about the bill.

In a show of bipartisanship, Democrats and Republicans worked Thursday to defeat it by a 103-37 vote.

Following the vote, Sharkey said Williams never had a conversation with him about the legislation.

“I’ve never, ever been consulted about this bill by anyone in the Senate,” Sharkey said. “And the advocates wanted a vote on the bill, so I thought it was important to have vote and avoid the distraction that was going to inevitably occur if we kept it on our calendar.”

He said the same thing happened last year with the GMO labeling bill, which bounced back and forth between chambers before finally winning the approval of all the stakeholders.

Sharkey said he voted against the GMO grass bill because he believes there should have been a public hearing.

“It’s too important to take up and do without getting input from all those stakeholders,” Sharkey said.

Genetically modified grass isn’t on the market yet, but supporters worry about what will happen if it gets out there. Proponents of the legislation say the genetically modified grass would increase the use of glyphosate or other herbicides because it would be resistant to those herbicides.

There’s also the threat of the seed spreading and cross-pollinating with other grass species and spreading individual genes from one species to another. This could lead to an artificially modified gene spreading into the broader gene pool, with untold consequences, Williams explained Wednesday during the Senate debate.

However, opponents of the legislation say it sends a bad message to business and scientists.

“We have a bill before us that says if some business out there is even thinking — thinking — about making such a thing, don’t bother cause you ain’t gonna sell it in Connecticut,” House Minority Leader Lawrence Cafero, R-Norwalk, said.

House Minority Leader Lawrence Cafero

House Minority Leader Lawrence Cafero

Cafero thought the concept was absurd.

“It doesn’t even exist and we’re going to ban it,” Cafero said. “Put down your beakers, put down your microscopes . . . save your time, change professions, ‘cause you ain’t doing it in Connecticut. Are you kidding me? Are you kidding me?”

A number of lawmakers, even those who supported the bill, said they were insulted the bill wasn’t raised for a public hearing.

“I don’t know anything about the substance to feel comfortable voting on this,” Rep. Michael D’Agostino, D-Hamden, said.

Rep. Mary Mushinsky, D-Wallingford, said she was concerned about how the bill came to the Environment Committee, but she worries the product will be sold next year. She said she believes it could be dangerous to the environment.

“This is our one chance to make this product go away before it arrives in the state,” Mushinsky said.

Lance Latham, a spokesman for Scotts MiracleGro, which is developing a genetically engineered grass seed, said Wednesday that it won’t be on the market for another “few years.”

“They’re welcome to visit our research facilities in Ohio, talk with our scientists and see firsthand why we believe our enhanced grass seed can one day bring about significant environmental benefits,” Latham said. “They’re also welcome to visit any of our facilities in Connecticut and meet with our 260 employees who live and work in the state.”

Despite the vote in the House, Williams said he was proud of what the Senate accomplished.

“Senate Democrats — joined by three Republicans — made history by taking a stand against the chemical companies and special interests which are poised to dump tens of thousands of gallons of pesticides on lawns across Connecticut,” Williams said.

Senate Majority Leader Martin M. Looney called the vote a disappointment.

“The House vote today is disappointing. Despite the fact that research has extensively documented the adverse impact of poisonous chemicals on human health and the environment, all too often government ignores the precautionary principle and takes action only after harm occurs,” Looney said.

In a statement, Senate Democrats said some of those who opposed the ban complained about the process, but failed to acknowledge that the initiative was discussed at two public hearings and that dozens of experts and citizens weighed-in. Organizations such as the Sierra Club and the CT League of Conservation Voters joined regular citizens in supporting the proposal.

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20

Dec
2013

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GMO Labeling

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Courant: New GMO Law Unnecessary

On 20, Dec 2013 | No Comments | In Featured, GMO Labeling | By admin

Courant.com

New GMO Law Unnecessary

A new law requires genetically modified food to be so labeled; the good news is that due to built-in qualifications, it can’t take effect yet.

“But there’s a catch, fortunately: The law won’t take effect until four other states enact similar legislation”

Read the rest of the article here